Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus
この論文をさがす
抄録
Article
In this study, the antiviral effects of bovine interferon-τ (boIFN-τ) on bovine viral diarrhea virus (BVDV) were examined in vitro and in vivo. In the in vitro experiments, the replication of cytopathic and non-cytopathic BVDV was inhibited in the bovine cells treated with boIFN-τ. The replication of BVDV was completely suppressed by boIFN-τ at a concentration higher than 10^<2> U/ml. In order to examine the effect of boIFN-τ on virus propagation in cattle persistently infected (PI) with non-cytopathic BVDV, boIFN-τ was subcutaneously administered to PI cattle at 10^<5> U/kg or 10^<6> U/kg body weight 5 times per week for 2 weeks. No physical abnormality such as depression was observed in the cattle during the experiment. The mean BVDV titers in the serum of the PI cattle decreased slightly during the boIFN-τ administration period with the dose of 10^<6> U/kg. However, the BVDV titers in the serum returned to the pre-administration level after the final boIFN-τ administration. These results suggest that boIFN-τ demonstrates an anti-BVDV effect, reducing the BVDV level in serum transiently when injected into PI cattle.
収録刊行物
-
- Japanese Journal of Veterinary Research
-
Japanese Journal of Veterinary Research 60 (2), 63-70, 2012-08
Graduate School of Veterinary Medicine, Hokkaido University
- Tweet
キーワード
詳細情報
-
- CRID
- 1390853649724094976
-
- NII論文ID
- 120004689050
-
- NII書誌ID
- AA0069128X
-
- HANDLE
- 2115/50095
- 10659/3488
-
- ISSN
- 00471917
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- CiNii Articles