Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration.

• 田村, 寛

• Tsujikawa, Akitaka

• Yamashiro, Kenji

• Akagi-Kurashige, Yumiko

• Nakata, Isao

• Nakanishi, Hideo

• Hayashi, Hisako

• Ooto, Sotaro

• Otani, Atsushi

• Yoshimura, Nagahisa

抄録

[Purpose]: To study the association of ARMS2 A69S genotype with the development of exudative age-related macular degeneration (AMD) in the unaffected fellow eye and to estimate the duration until the development of AMD in the second eye. [Design]: Retrospective cohort study. [Methods]: We retrospectively reviewed 326 patients who had exudative AMD in at least 1 eye, genotyping of ARMS2 A69S, and a minimum follow-up of 2 years. Survival analysis and Cox proportional hazard regression analysis were used to examine the association between candidate factors and the duration until the development of AMD in the second eye. [Results]: One hundred nineteen patients (36.5%) had bilateral exudative AMD at the initial visit. A risk allele of ARMS2 A69S was more frequently seen in patients with bilateral AMD (P = .0270) than in those with unilateral AMD. Of the 207 unilateral AMD patients, 23 (11.1%) had AMD in the fellow eye after a mean duration of 56.3 ± 40.4 months. Fellow-eye involvement was associated with ARMS2 A69S genotype (hazard ratio [HR], 2.673; P = .0013), age (HR, 1.102; P = .0005), and smoking history (HR, 0.680; P = .3663). As HRs indicate, correlation of genotype (2.673) was as high as that of 10-year aging (1.10210 = 2.641). Survival analysis revealed that patients with risk homozygous (TT) genotype had second-eye involvement significantly earlier than those with other genotypes (P = .0028). When the observation duration reached 120 months, second-eye involvement had developed in 50%, 6.6%, and 11.2% of the TT, GT, and GG cohorts, respectively. [Conclusion]: ARMS2 A69S genotype is associated with second-eye involvement of exudative AMD and with the period between first- and second-eye involvements.

収録刊行物

• American journal of ophthalmology

  American journal of ophthalmology 154 (3), 542-548.e1, 2012-09

  Elsevier Inc.

キーワード

• age-related macular degeneration
• second eye
• genotype
• ARMS2

詳細情報

• CRID: 1050564285693257472
• NII論文ID: 120004874011
• NII書誌ID: AA11523017
• ISSN: 00029394
• HANDLE: 2433/160394
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles