Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake.
この論文をさがす
抄録
Chemokine-dependent trafficking is indispensable for the effector function of antigen-experienced T cells during immune responses. In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions. T cell migration toward chemokines is dependent on AQP3-mediated hydrogen peroxide (H(2)O(2)) uptake but not the canonical water/glycerol transport. AQP3-mediated H(2)O(2) transport is essential for the activation of the Rho family GTPase Cdc42 and the subsequent actin dynamics. Coincidentally, AQP3-deficient mice are defective in the development of hapten-induced contact hypersensitivity, which is attributed to the impaired trafficking of antigen-primed T cells to the hapten-challenged skin. We therefore suggest that AQP3-mediated H(2)O(2) uptake is required for chemokine-dependent T cell migration in sufficient immune response.
収録刊行物
-
- The Journal of experimental medicine
-
The Journal of experimental medicine 209 (10), 1743-1752, 2012-09-24
The Rockefeller University Press
- Tweet
キーワード
- Actins/metabolism
- Animals
- Aquaporin 3/genetics
- Aquaporin 3/metabolism
- Biological Transport
- Cell Movement/immunology
- Chemokine CXCL12/immunology
- Chemokines/immunology
- Chemotaxis, Leukocyte/immunology
- Gene Expression Regulation
- Humans
- Hydrogen Peroxide/metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Permeability
- Protein Multimerization/immunology
- Signal Transduction
- Skin/immunology
- T-Lymphocytes/immunology
- T-Lymphocytes/metabolism
- Water/metabolism
- cdc42 GTP-Binding Protein/metabolism
詳細情報 詳細情報について
-
- CRID
- 1050282810729970688
-
- NII論文ID
- 120005054804
-
- NII書誌ID
- AA00697559
-
- ISSN
- 15409538
-
- HANDLE
- 2433/166329
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- CiNii Articles