熱帯地における主なウイルス性出血熱,原虫感染症,中毒性疾患の肝臓病変

• 板倉, 英世

書誌事項

タイトル別名

• Liver Diseases in the Tropics
• ネッタイチ ニ オケル オモナ ウイルスセイ シュッケツネツ, ゲンチュウ カンセンショウ, チュウドクセイ シッカン ノ カンゾウ ビョウヘン

抄録

There are a lot of liver diseases in the tropics. Yellow fever is one of viralhemorrhagic fevers which exert influence upon the liver. Midzonal necrosis andCouncilman body are characteristic histological features of the liver. Hemorrhagic fevers such as Lassa fever, Marburg virus disease and Ebola hemorrhagic fever show more or less irregular degenerative and necrotic changes of liver parenchymal cells with relatively slight inflammatory cell infiltration. Characteristic bile stasis of peripheral region of liver lobules and foamy degeneration of liver parenchymal cells are observed in the liver in Hemorrhagic Fever with Renal Syndrome (Korean Hemorrhagic Fever). Dengue Hemorrhagic Fever and Rift Valley fever also affect the liver.Although malaria itself is not liver disease, remarkable mobilization of Kupffercalls containing malarial parasites is observed occasionally. In experimental malaria using mice, scattered acidophilic necrosis of liver parenchymal cells is seen. In chronic malaria, probably tertian malaria, liver usually shows only deposition of malarial pigments in some Kupffer cells with no or very slight parenchymal lesionor fibrosis. In visceral Leishmaniasis, Kala-azar, parasites could be seen innot only Kupffer cells but also liver parenchymal cells.Pericholangiolar inflammatory cell infiltration and fibrosis of the liver occurin clonorchiasis and fascioliasis, because the parasites infect bile system of theliver. Unilocular echinoccosis is seen in Africa and other tropical areas. Largecyst formation cause mechanical disturbance of the liver. Schistosomiasis japonicaand mansoni are prevalent in tropical areas, and fibrosis or cirrhosis of the livercan be observed.Mycotoxicosis especially acute aflatoxicosis is sometimes reported in tropicalareas. Whether mycotoxins play etiological role of primary hepatocellular carcinomaof man is not known. Reye's syndrome and kwashiorkor are related to nutritionaldisturbances or malnutrition showing fatty metamorphosis of liver parenchymal cells. In Bantu siderosis, diffuse iron deposition is observed in the liver both inKupffer cells and liver parenchymal cells. Iron overload through oral intake isconsidered as etiology.Viral hepatitis A, viral hepatitis B and non-A, non-B hepatitis are alsoprevalent in the Tropics.

板倉英世（長崎大学熱帯医学研究所病理学部門）

収録刊行物

• 南方海域調査研究報告=Occasional Papers

  南方海域調査研究報告=Occasional Papers 6 49-60,

  鹿児島大学

詳細情報

• CRID: 1050001202537111680
• NII論文ID: 120005197119
• NII書誌ID: AN10030752
• ISSN: 02892707
• Web Site: http://hdl.handle.net/10232/15904
• 本文言語コード: ja
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles