Dielectric spectroscopy reveals nanoholes in erythrocyte ghosts
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When blood is diluted with water, erythrocytes swell and then burst to release haemoglobin molecules, viz. hypotonic hemolysis. The remaining membranes, so-called “ghosts”, have transient holes, which are resealed under physiological conditions. About 50 years ago it was reported that ghost suspensions showed peculiar dielectric dispersion below 10 kHz, termed α-dispersion, which was not found for intact erythrocyte suspensions. The finding, however, has never been traced because of difficulty in low-frequency measurement due to electrode polarization (EP) effects, and therefore the origin of the α-dispersion has not been understood. In this study, the α-dispersion has been revealed using a new type of measurement cell capable of reducing the EP effects. The properties of the α-dispersion were exactly interpreted by modelling ghosts as a spherical cell with a single hole. The numerical simulation with the cell model provided a linear relation between the characteristic frequency of the α-dispersion and the hole radius, the hole radius thereby being determined straightforwardly.
収録刊行物
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- Soft Matter
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Soft Matter 8 3250-3257, 2012-02-10
Royal Society of Chemistry
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詳細情報 詳細情報について
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- CRID
- 1050564285712652288
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- NII論文ID
- 120005241350
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- NII書誌ID
- AA12068335
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- ISSN
- 1744683X
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- HANDLE
- 2433/169684
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles