Synthetic study of perophoramidine: construction of pentacyclic core structure via SmI2-mediated reductive cyclization
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抄録
An intramolecular SmI2-mediated reductive cyclization of carbodiimides and unsaturated lactams was applied to functionalized substrates bearing tetrasubstituted olefins. The reaction afforded arylated spiro-2-iminoindolines in high yield. Although the stereochemistry of the product was different from the desired one, the optimized palladium-catalyzed aryl amidination realized the isomerization and C–N bond formation in a single step and resulted in efficient construction of pentacyclic core of perophoramidine synthetically equivalent to the Rainier's intermediate.
収録刊行物
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- Tetrahedron
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Tetrahedron 69 (23), 4517-4523, 2013-06
Elsevier Ltd.
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詳細情報 詳細情報について
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- CRID
- 1050282810746491776
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- NII論文ID
- 120005244917
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- NII書誌ID
- AA00861787
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- ISSN
- 00404020
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- HANDLE
- 2433/174063
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
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- CiNii Articles
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