Metabolic syndrome is not a predictor for cardiovascular events in Japanese patients with diabetes mellitus asymptomatic for coronary artery disease: A retrospective analysis of the J-ACCESS-2 study

• Nakajima, Kenichi

• Takeishi, Yasuchika

• Matsuo, Shinro

• Yamasaki, Yoshimitsu

• Nishimura, Tsunehiko

抄録

Purpose: Patients with metabolic syndrome (MetS) have potentially higher risk for cardiovascular events. The aim of this study was to evaluate the effect of MetS on cardiac events in type-2 diabetic patients asymptomatic for coronary artery disease (CAD) in a Japanese population. Methods: A total of 485 patients from a J-ACCESS-2 investigation with stress-gated myocardial perfusion imaging (MPI) and quantitative-gated MPI analysis were examined. Cardiovascular hard events (cardiac death and acute coronary syndrome) and total events during a 3-year follow-up were analyzed. Results: The MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256). The hard events were 8 and 12 for the MetS and non-MetS groups (P = n.s.), and total events were 31 and 31 for each of these groups, respectively (P = n.s.). Significant variables related to total cardiovascular events included age, current smoking, insulin use, total cholesterol, ejection fraction, summed stress score ≥ 9, and summed difference score ≥ 2. Cox proportional hazard analysis and Kaplan-Meier survival analysis showed that only the summed stress score was related to total events (P = .01), and the presence and the number of items for MetS criteria were not. Conclusion: In patients with type 2 diabetes asymptomatic for CAD, cardiovascular events and ischemia are as common in diabetic patients without MetS as in those with MetS. A high MPI defect score is related to total events including cardiac and cerebrovascular events. © 2012 American Society of Nuclear Cardiology.

収録刊行物

• Journal of Nuclear Cardiology

  Journal of Nuclear Cardiology 20 (2), 234-241, 2013-04-01

  American Society of Nuclear Cardiology (ASNC) / Springer Verlag (Germany)

キーワード

• Metabolic syndrome
• myocardial perfusion imaging
• prognosis
• SPECT imaging
• type 2 diabetes

詳細情報

• CRID: 1050001335950801536
• NII論文ID: 120005253206
• NII書誌ID: AA11016223
• ISSN: 10713581
• Web Site: http://hdl.handle.net/2297/33408
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles