Molecular machines directly observed by high-speed atomic force microscopy

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Molecular machines made of proteins are highly dynamic and carry out sophisticated biological functions. The direct and dynamic high-resolution visualization of molecular machines in action is considered to be the most straightforward approach to understanding how they function but this has long been infeasible until recently. High-speed atomic force microscopy has recently been realized, making such visualization possible. The captured images of myosin V, F1-ATPase, and bacteriorhodopsin have enabled their dynamic processes and structure dynamics to be revealed in great detail, giving unique and deep insights into their functional mechanisms. © 2013 Federation of European Biochemical Societies.

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  • FEBS Letters

    FEBS Letters 587 (8), 997-1007, 2013-04-17

    Federation of European Biochemical Societies / Elsevier

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