Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese

• Inoue Kiyomi

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Sakano Noriko

  Department of Hygiene, Faculty of Medicine, Kagawa University

• Ogino Keiki

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Sato Yoshie

  Graduate School of Health Sciences, Okayama University

• Wang Da-Hong

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kubo Masayuki

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Takahashi Hidekazu

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kanbara Sakiko

  Graduate School of Nursing, University of Kochi

• Miyatake Nobuyuki

  Department of Hygiene, Faculty of Medicine, Kagawa University

抄録

Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson’s disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H₂O₂, 8-hydroxy-2’-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 ± 10.0 (year), CP; 31.9 ± 6.8 (mg/dl), ferritin; 123.5 ± 121.0 (ng/ml), hs-CRP; 0.89 ± 2.53 (mg/l), 8-OHdG; 10.2 ± 4.4 [ng/mg creatinine (Cre)] and H₂O₂; 6.5 ± 10.9 (µM/g Cre), (All data mentioned above were expressed as mean ± SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hs-CRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 52 (2), 160-166, 2013

  一般社団法人　日本酸化ストレス学会

キーワード

• ceruloplasmin
• ferritin
• 8-OHdG
• oxidative stress
• high-sensitivity C-reactive protein

詳細情報

• CRID: 1390282679648887040
• NII論文ID: 130004466707
• NII論文ID: 120005315580
• NII書誌ID: AA10710201
• DOI: 10.3164/jcbn.12-122
• COI: 1:CAS:528:DC%2BC3sXlslyku7w%3D
• ISSN: 18805086
• ISSN: 09120009
• PubMed: 23524455
• Web Site: https://ousar.lib.okayama-u.ac.jp/51031
• Web Site: https://search.jamas.or.jp/link/ui/2014010996
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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