非環式レチノイドは血小板由来増殖因子(PDGF)-C 過剰発現肝発癌モデルマウスの肝線維化・肝発癌を抑制する

• 岡田, 光

書誌事項

タイトル別名

• Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development

抄録

Hepatocellular carcinoma (HCC) often develops in association with liver cirrhosis, and its high recurrence rate leads to poor patient prognosis. Although recent evidence suggests that peretinoin, a member of the acyclic retinoid family, may be an effective chemopreventive drug for HCC, published data about its effects on hepatic mesenchymal cells, such as stellate cells and endothelial cells, remain limited. Using a mouse model in which platelet-derived growth factor (PDGF)-C is overexpressed (Pdgf-c Tg), resulting in hepatic fibrosis, steatosis, and eventually, HCC development, we show that peretinoin significantly represses the development of hepatic fibrosis and tumors. Peretinoin inhibited the signaling pathways of fibrogenesis, angiogenesis, and Wnt/β-catenin in Pdgfc transgenic mice. In vitro, peretinoin repressed the expression of PDGF receptors α/β in primary mouse hepatic stellate cells (HSC), hepatoma cells, fibroblasts, and endothelial cells. Peretinoin also inhibited PDGF-C-activated transformation of HSCs into myofibroblasts. Together, our findings show that PDGF signaling is a target of peretinoin in preventing the development of hepatic fibrosis and HCC. ©2012 AACR.

[総説 / Reviews][博士課程優秀論文] 第11回 高安賞優秀論文賞受賞論文, Cancer Research 72 (17) , pp. 4459-4471(2012年9月掲載), Hikari Okada, Masao Honda, Jean S. Campbe, Yoshio Sakai, Taro Yamashita, Yuuki Takebuchi, Kazuhiro Hada, Takayoshi Shirasaki, Riuta Takabatake, Mikiko Nakamura,Hajime Sunagozaka, Takuji Tanaka, Nelson Fausto, and Shuichi Kaneko "Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development." http://dx.doi.org/10.1158/0008-5472.CAN-12-0028

収録刊行物

• 金沢大学十全医学会雑誌 = Journal of the Juzen Medical Society

  金沢大学十全医学会雑誌 = Journal of the Juzen Medical Society 122 (2), 35-36, 2013-06-01

  金沢大学十全医学会 = The Juzen Medical Society Kanazawa University

詳細情報

• CRID: 1050001202740462592
• NII論文ID: 10031193193
• NII書誌ID: AN00044397
• ISSN: 00227226
• Web Site: http://hdl.handle.net/2297/35532
• 本文言語コード: ja
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles