Ca2+-binding properties and regulatory roles of lobster troponin C sites II and IV
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抄録
Invertebrate troponin C typically contains Ca2+-specific binding sites, sites II and IV, in the N- and C-terminal domains, respectively. To investigate the roles of these sites for Ca2+-dependent regulation of muscle contraction, we generated lobster troponin C mutants, and analyzed their Ca2+-binding properties and regulatory effects on actomyosin-tropomyosin Mg-ATPase activity. The results suggest that Ca2+ binding to site IV is responsible for regulation at relatively low Ca2+ concentrations, while site II has an essential role in full activation at higher Ca2+ concentrations. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
収録刊行物
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- Febs letters
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Febs letters 587 (16), 2612-2616, 2013-08-19
Elsevier science bv
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詳細情報
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- CRID
- 1050564288967879424
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- NII論文ID
- 120005326754
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- NII書誌ID
- AA00642943
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- HANDLE
- 2115/53273
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- ISSN
- 00145793
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles