Ca2+-binding properties and regulatory roles of lobster troponin C sites II and IV

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抄録

Invertebrate troponin C typically contains Ca2+-specific binding sites, sites II and IV, in the N- and C-terminal domains, respectively. To investigate the roles of these sites for Ca2+-dependent regulation of muscle contraction, we generated lobster troponin C mutants, and analyzed their Ca2+-binding properties and regulatory effects on actomyosin-tropomyosin Mg-ATPase activity. The results suggest that Ca2+ binding to site IV is responsible for regulation at relatively low Ca2+ concentrations, while site II has an essential role in full activation at higher Ca2+ concentrations. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

収録刊行物

  • Febs letters

    Febs letters 587 (16), 2612-2616, 2013-08-19

    Elsevier science bv

詳細情報

  • CRID
    1050564288967879424
  • NII論文ID
    120005326754
  • NII書誌ID
    AA00642943
  • HANDLE
    2115/53273
  • ISSN
    00145793
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles

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