Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway

• Goudarzi, Houman

• Iizasa, Hisashi

• Furuhashi, Masako

• Nakazawa, Seitaro

• Nakane, Rie

• Liang, Shanshan

• Hida, Yasuhiro

• Yanagihara, Kazuyoshi

• Kubo, Takanori

• Nakagawa, Koji

• Kobayashi, Masanobu

• Irimura, Tatsuro

• Hamada, Jun-ichi

抄録

In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (I) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.

収録刊行物

• Cancer letters

  Cancer letters 339 (1), 82-92, 2013-10-01

  Elsevier ireland ltd

キーワード

• Mesothelioma
• Hypoxia
• HIF
• MUC1
• Motility
• Invasiveness

詳細情報

• CRID: 1050845763944642304
• NII論文ID: 120005345323
• NII書誌ID: AA00598513
• HANDLE: 2115/53474
• ISSN: 03043835
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles