ビカルタミド治療中に乳房痛を発現した前立腺癌患者に対するフルタミドへの変更療法の有用性に関する研究

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タイトル別名
  • Effect of Change to Flutamide for Prostate Cancer Patient who Developed Breast Pain during Bicalutamide Treatment (BIP-F Study)
  • ビカルタミド チリョウ チュウ ニ チブサツウ オ ハツゲン シタ ゼンリツセン ガン カンジャ ニ タイスル フルタミド エ ノ ヘンコウ リョウホウ ノ ユウヨウセイ ニ カンスル ケンキュウ

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抄録

In Japan, prostate cancer is treated with non-steroidal anti-androgen (flutamide and bicalutamide). Development of breast pain during bicalutamide treatment, in prostate cancer patients reduces their quality of life (QOL) and treatment compliance. We studied the safety and effectiveness of switching from bicalutamide to flutamide in 13 prostate cancer patients who developed breast pain during bicalutamide treatment. We estimated the change in breast pain using a face scale and the Expanded Prostate Cancer Index Composite (EPIC) and EPIC-hormone domain (HD) score. The switch to flutamide relieved breast pain in nine patients, had no effect in one patient, and increased breast pain in two patients. One patient dropped out. Furthermore, summary score and hormone function were improved with a significant difference in the EPIC-HD score. Switching to flutamide in prostate cancer patients who develop breast pain during bicalutamide is safe and effective.

収録刊行物

  • 泌尿器科紀要

    泌尿器科紀要 60 (1), 17-23, 2014-01

    泌尿器科紀要刊行会

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