尿膜管癌多発肺転移に対しTS-1/CDDP 療法を施行した1例

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タイトル別名
  • A Case of Urachal Carcinoma with Multiple Lung Metastases Treated by TS-1/CDDP Chemotherapy
  • ニョウマクカンガン タハツ ハイ テンイ ニ タイシ TS-1/CDDP リョウホウ オ シコウ シタ 1レイ

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A 67-year-old woman presented with macroscopic hematuria and lower abdominal pain. Cystoscopy revealed a broad-stalk non-papillary tumor at the bladder dome. Computed tomography (CT) showed a tumor extending from the umbilicus to the bladder dome, together with multiple lung metastases. Serum carcinoembryonic antigen and cancer antigen (CA19-9) levels were elevated at 7.0 ng/ml and 180 U/ml, respectively. Transurethral resection of the tumor was performed and histopathology revealed adenocarcinoma. Therefore, the tumor was diagnosed as a stage IVB (Sheldon's category) urachal carcinoma. En bloc segmental resection of the urachal carcinoma with the bladder dome was performed, followed by chemotherapy with tegafur, gimestat, and otastat potassium (TS-1) and cisplatin. The disease remained stable for 8 months. However, a follow up CT scan after 11 chemotherapy cycles showed progression of the lung metastases. In spite of the change to a second-line gemcitabine and cisplatin chemotherapy regimen, the disease continued to progress after 4 cycles.

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  • 泌尿器科紀要

    泌尿器科紀要 60 (3), 147-150, 2014-03

    泌尿器科紀要刊行会

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