ラットの臓器及び脂肪組織に対する後肢ギプス固定除去の影響

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  • ラット ノ ゾウキ オヨビ シボウ ソシキ ニ タイスル コウシ ギプス コテイ ジョキョ ノ エイキョウ
  • Effects of Recovery after Casted-immobilization and Removal on Visceral Organs and Adipose Tissue in the Rat.

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We studied the effects of cast immobilization on the weight of visceral organs and adipose tissue in mature male Sprague-Dawley rats (8 weeks old). The animals were divided into four groups: 10 weeks sedentary control (10S;n=7) ， 10 days cast-immobilized (CAS;n=7) ， 10 weeks sedentary control + 1 week sedentary recovery corresponding to the recovery period of the casted groups (11S;n=4)， and 1 week recovery after cast removal (RCAS;n=6) . In the CAS and RCAS groups. the cast immobilized the knee and foot joints. For the RCAS group， the casts were removed after 10 days， and the animals were allowed to move freely during 7 days. Groups 10S and CAS were introduced in this study after 10 days of cast immobilization. Groups 11S and RCAS were introduced in this study after 7 days after cast removal. The visceral organs (heart ， liver ， spleen ， adrenal gland ， and kidney) and adipose tissue［intracapsular brown adipose tissue (IBAT) as well as perirenal， epididymal and subcutaneous tissues of the groin] were isolated and weighed. The lipid and protein contents of IBAT were also measured.At the end of the treatment periods， heart weight was significantly lower in the RCAS group than in the CAS group . There was no statistical difference between the groups for the weights of the other visceral organs and IBAT. The mean and relative weights of epididymal white adipose tissue were significantly higher in the 11S group than in the CAS group. The IBAT composition was not significantly different between the groups.Collectively， these data indicate that the effects of cast immobilization and removal differ between visceral organs or adipose tissues.

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