Inhalation Administration of Valerena-4,7(11)-diene from Nardostachys chinensis Roots Ameliorates Restraint Stress-Induced Changes in Murine Behavior and Stress-Related Factors

• Takemoto Hiroaki

  School of Pharmacy, Kitasato University

• Omameuda Yuka

  School of Pharmacy, Kitasato University

• Ito Michiho

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Fukuda Tatsuo

  School of Pharmacy, Kitasato University

• Kaneko Shuji

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Akaike Akinori

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Kobayashi Yoshinori

  School of Pharmacy, Kitasato University

書誌事項

タイトル別名

• Inhalation Administration of Valerena-4,7(11)-diene from <i>Nardostachys chinensis</i> Roots Ameliorates Restraint Stress-Induced Changes in Murine Behavior and Stress-Related Factors

抄録

Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4,7(11)-diene (VLD) from this plant. In the present study, we investigated stress reducing effects of VLD and the associated mechanisms of action. Application of 15-min restraint stresses induced excitatory behaviors in mice. Immobility times in the forced swim test and sleeping times in the pentobarbital sleep test were shortened in the stressed group by 47% and 43%, respectively, compared with the control group. Furthermore, restraint stress increased serum corticosterone levels by 75%, and cerebral serotonin (5-HT) and dopamine (DA) levels. Inhaled VLD (300 µg/cage) suppressed stress-induced excitatory behaviors and significantly reduced stress-induced blood corticosterone, cerebral 5-HT, and DA levels. These results suggest that VLD interacts with the hypothalamic–pituitary–adrenal axis and the sympathetic-adrenomedullary system. These interactions appear to involve GABAergic and D₂ antagonist activities. Moreover, tests in anosmic and intravenously treated mice showed that the sedative effect of inhaled VLD was expressed via olfactory stimulation and pulmonary absorption. Although more studies are required to further elucidate the properties of this compound, our studies suggest that VLD may be an effective anti-stress aromatherapy for humans.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 37 (6), 1050-1055, 2014

  公益社団法人 日本薬学会

キーワード

• <i>Nardostachys chinensis</i>
• valerena-4,7(11)-diene
• anti-stress effect
• inhalation

詳細情報

• CRID: 1390282679607993984
• NII論文ID: 130004147352
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b14-00136
• COI: 1:STN:280:DC%2BC2cjot1Ggtg%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• HANDLE: 2433/188917
• NDL書誌ID: 025478989
• PubMed: 24882416
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025478989
• Web Site: https://www.jstage.jst.go.jp/article/bpb/37/6/37_b14-00136/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015049396
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可