Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

• Koyama, Motoko

• Hashimoto, Daigo

• Nagafuji, Koji

• Eto, Tetsuya

• Ohno, Yuju

• Aoyama, Kazutoshi

• Iwasaki, Hiromi

• Miyamoto, Toshihiro

• Hill, Geoffrey R.

• Akashi, Koichi

• Teshima, Takanori

抄録

Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.

収録刊行物

• Bone Marrow Transplantation

  Bone Marrow Transplantation 49 (1), 110-115, 2014-01

  Nature Publishing Group

キーワード

• graft rejection
• bone marrow transplantation
• cord blood transplantation

詳細情報

• CRID: 1050282813991246720
• NII論文ID: 120005460247
• NII書誌ID: AA10673987
• ISSN: 14765365
• ISSN: 02683369
• HANDLE: 2115/56649
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles