グレリンの腹腔内投与が栄養素選択的な摂食調節に及ぼす影響

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  • The Effect of Ghrelin Infusion Intraperitoneally to the Control of Food Intake with Nutrient Selection
  • グレリン ノ フククウナイ トウヨ ガ エイヨウソ センタクテキナ セッショク チョウセツ ニ オヨボス エイキョウ

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Ghrelin is a 28-amino acid peptide with an acyl side chain, n-octanoic acid. It was reported that ghrelin infusion centrally and peripherally increases food intake. In this study, to investigate the effect of ghrelin to preference on nutrients, we infused ghrelin (0.5, 1.0 and 5.0 nmol/rat) intraperitoneally to rats, which were fed simultaneously three macronutrient diets (carbohydrate, protein and fat), and measured food intakes at 1, 2 and 4hr after infusion. Infusions of ghrelin increased dose-dependently total food intake compared with saline infusion. Infusion of ghrelin increased significantly carbohydrate intake, although protein and fat intakes did not altered. Serum glucose, total protein, albumin, triglyceride, free fatty acid and β-lipoprotein levels were did not altered with infusion of ghrelin. This study defined that ghrelin infusion increased selectively carbohydrate intake without metabolic changes. This result suggests that ghrelin may participate directly with the selective control of carbohydrate intake.

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