Oral Administration of Fexofenadine Hydrochloride can Attenuate Nasal Symptoms and Restore the Impaired Cognitive Function in School-Age Patients with Japanese Cedar Pollinosis
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抄録
We conducted a well-controlled observational study attempting to examine whether decreased cognitive functions caused by Japanese cedar pollinosis could be improved by oral administration of fexofenadine hydrochloride particularly in school-age patients. Cognitive functions were evaluated before and after the treatment by employing Trail Making tests (TMT). Participating patients answered a questionnaire about treatment effects and their satisfaction with fexofenadine hydrochloride. A total of 54 patients aged 7 to 16 were enrolled in this study. A significant improvement was observed with two kinds of TMT (P<0.0001 for both). The overall ratio of positive answers to the question of overall satisfaction with the drug, concentration in the classroom, symptoms, inconvenience in daily life, and night-time sleep were 88.5%, 71.1%, 88.7%, 60.0%, and 65.3%, respectively. These results taken together suggest that treatment with fexofenadine hydrochloride actually restores nasal symptom-derived decreases in cognitive functions, with no impairment of cognitive functions by the central nervous system (CNS) depressant actions.
収録刊行物
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- Shimane journal of medical science
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Shimane journal of medical science 29 (2), 79-86, 2013-02-01
Shimane University Faculty of Medicine
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詳細情報 詳細情報について
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- CRID
- 1050001339310315008
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- NII論文ID
- 120005587420
- 110009591609
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- NII書誌ID
- AA00841586
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- ISSN
- 03865959
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- CiNii Articles