Constituents of the Leaves of Odontioda Marie Noel 'Velano' with Inhibitory Activity on RANKL-induced Osteoclast Differentiation :

  • Watanabe,Mio
    Department of Pharmacognosy and Natural Medicines, Faculty of Pharmaceutical Sciences, Josai University
  • Suzuki,Ryuichiro
    Department of Pharmacognosy and Natural Medicines, Faculty of Pharmaceutical Sciences, Josai University
  • Tomomura,Mineko
    Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry
  • Sakagami,Hiroshi
    Division of Pharmacology, Meikai University School of Dentistry
  • Tomomura,Akito
    Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry
  • Shirataki,Yoshiaki
    Department of Pharmacognosy and Natural Medicines, Faculty of Pharmaceutical Sciences, Josai University

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Four compounds (1-4) were isolated from the leaves of Odontioda Marie Noel 'Velano'. 2-4 were identified as phenanthrene derivatives with spectroscopic analysis. 2 reported here was isolated for the first time from this plant. Among them, 2 and 3 potently inhibited the receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclast differentiation.

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