MUC5AC-negative phenotype is correlated with poor patient prognosis of pancreas head ductal carcinoma.

DOI 機関リポジトリ HANDLE Web Site
  • Sakuraba Shingo
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Morohashi Satoko
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
  • Yoshizawa Tadashi
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
  • Tsutsumi Shinji
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kimura Norihisa
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kudo Daisuke
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Ishido Keinosuke
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Toyoki Yoshikazu
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Hakamada Kenichi
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine
  • Kijima Hiroshi
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine

この論文をさがす

抄録

    Both pancreas head ductal carcinoma (PHDC) and distal bile duct carcinoma (DBDC) are located within the pancreas head/intra-pancreatic bile duct region, and are the most aggressive malignancies with poor patient prognosis. In the present study, we demonstrated clinicopathological features and patients prognosis of PHDC/DBDC. We examined total 87 surgically resected cases of PHDC (40 cases) and DBDC (47 cases). PHDC showed frequent neural invasion (85.0%) and lymph node metastasis (77.5%), compared with DBDC (57.4% and 40.4% respectively), resulting in the poorer prognosis (P=0.0219) than DBDC. In addition, PHDC expressed MUC2 (10.0%) and MUC6 (25.0%) less frequently, compared with DBDC (36.2% and 55.3%, respectively). MUC5AC-negative PHDC exhibited significantly poorer patient’s prognosis, compared with MUC5AC-positive PHDC (P=0.0111), MUC5ACpositive DBDC (P=0.000162), and MUC5AC-negative DBDC (P=0.00416). In conclusion, MUC5AC-negative PHDC showed significantly poor patient's prognosis.

収録刊行物

  • 弘前医学

    弘前医学 66 (1), 28-37, 2015

    弘前大学大学院医学研究科・弘前医学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ