A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin

• Hasebe, Akira

• Mu, Hong-Hua

• Cole, Barry C

抄録

PROBLEM: Mycoplasma hominis has been implicated in many inflammatory conditions of the human urogenital tract in particular amniotic infections that lead to fetal and neonatal disease and pre-term labor. The mechanisms responsible are poorly defined. METHOD OF STUDY: Biochemical and immunological methods were used to extract, purify, and characterize an inflammatory component present in M. hominis. RESULTS: We isolated and purified to homogeneity a 40-kDa bioactive lipoprotein from M. hominis that was a potent TLR2-dependent, CD14-independent activator of the human THP-1 macrophage cell line. Homology searches of the N-terminal sequence revealed that 22 of the first 23 residues were identical to those seen for the phase-variable M. hominis p50 adhesin. The truncated P50t lipoprotein importantly retained its adhesive properties for human macrophages. CONCLUSION: The unique adhesin/macrophage activator may play a key role in M. hominis infections by triggering an inflammatory cytokine cascade.

収録刊行物

• American Journal of Reproductive Immunology

  American Journal of Reproductive Immunology 72 (3), 285-295, 2014-06-17

  Wiley-Blackwell

キーワード

• Adhesin
• TLR2
• genital mycoplasmosis
• macrophage

詳細情報

• CRID: 1050845763946935808
• NII論文ID: 120005615511
• NII書誌ID: AA10729786
• ISSN: 16000897
• ISSN: 10467408
• HANDLE: 2115/59366
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles