宿主体内生存戦略のための大腸菌ゲノム制御ネットワークの研究

• 山中, 幸

書誌事項

タイトル別名

• STUDIES ON THE GENOME REGULATORY NETWORK FOR SURVIVAL WITHIN HOST ANIMALS IN ESCHERICHIA COLI

抄録

type:Article

During colonization of the gastrointestinal tract, enterobacteria construct a hierarchic regulatory network of genome expression to adapt to environmental stresses. My studies revealed novel cascade regulations by YdeO and GadE, which are transcriptional factors known to control the glutamate-dependent acid resistance system in Escherichia coli. YdeO forms the characterized two transcriptional cascades, YdeO > YiiS > CadC and YdeO > GadE for controlling two acid resistance systems, which are dependent on glutamate and lysine. Moreover, GadE induced by YdeO forms other regulatory cascades, GadE > HdeD > LrhA > FlhDC and GadE > HdeD > GadX. Taking all the results together, my thesis presents a hierarchic multi-regulatory network followed by acid resistance factors to achieve colonization in a large intestine within host animals.

収録刊行物

• 法政大学大学院紀要. 理工学・工学研究科編

  法政大学大学院紀要. 理工学・工学研究科編 56 1-4, 2015-03-24

  法政大学大学院理工学・工学研究科

キーワード

• Escherichia coli
• regulatory network
• acid resistance
• YdeO
• GadE

詳細情報

• CRID: 1050298919736799872
• NII論文ID: 120005623558
• NII書誌ID: AA12677220
• ISSN: 21879923
• Web Site: http://hdl.handle.net/10114/11034
• 本文言語コード: ja
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles