Effects of Acute Arterial Bleeding on Renal Sympathetic Nerve Activity in Young and Old Anesthetized Rats

• Kohata, Shuji

• Ninomiya, Isio

• Shinizu, Junichi

• Furukawa, Kazuto

• Matsuura, Yuichiro

抄録

We compared the change in renal sympathetic nerve activity (RNA) during hemorrhage in young and old rats. Young (10 weeks) and old (80 weeks) male Wistar rats were anesthetized, and RNA together with arterial pressure (AP) and heart rate (HR) were measured under spontaneous respiration. Acute arterial bleeding, lm1Jl00g body weight, was carried out to induce hypotension and hypovolemia. With bleeding, mean AP (MAP) decreased from 110 ± 12 to 23 ± 11mmHg (mean ± SEM) and from 93 ± 15 to 15 ± 6mmHg in young and old rats, respectively. The difference in the change of MAP between the young and old rats was not significant. With bleeding, mean RNA increased by 46 ± 21 % and 20 ± 16% in young and old rats, respectively. The increase in mean RNA of the old rats was significantly lower than that of the young rats. We estimated the gain of the barocepter-renal sympathetic nervous system by using the formula ∆RNA/RNA/∆MAP/MAP. The gain was 0.61 ± 0.34 and 0.23 ± 0.18 in young and old rats, respectively. The difference in the gain was statistically significant (p<0.05). We concluded that the gain of baroceptor-sympathetic nerve system in acute arterial hemorrhage is attenuated with aging.

収録刊行物

• Hiroshima Journal of Medical Sciences

  Hiroshima Journal of Medical Sciences 46 (3), 87-92, 1997-09

  Hiroshima University Medical Press

キーワード

• Renal nerve activity
• Acute arterial bleeding
• Aging

詳細情報

• CRID: 1050577740962036736
• NII論文ID: 120005624369
• NII書誌ID: AA00664312
• Web Site: http://ir.lib.hiroshima-u.ac.jp/00037822
• 本文言語コード: en
• 資料種別: departmental bulletin paper
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  • CiNii Articles