ラット後肢骨格筋に対するギプス固定解除の影響

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  • ラット コウシ コッカクキン ニ タイスル ギプス コテイ カイジョ ノ エイキョウ
  • Effects of the Removal of the Cast on Hindlimb Skeletal Muscle in Rats.

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We studied the effects of continuous cast immobilization and those after removal of the cast on the weights of hindlimb skeletal muscles in male mature Sprague-Dawley rats (8 weeks old). The animals were divided into three groups: sedentary control (n = 6)， cast-immobilized (CAS; n = 5) and recovery after cast-immobilization off (RCAS; n=5). Animals in the CAS and RCAS groups were immobilized at the knee and foot joints for 10 days. After 10 days of immobilization， rats in the RCAS group were released from the cast and were reared in normal conditions for 7 days. Rats in the sedentary control and CAS group were provided after 10 days of cast-immobilization and those in the RCAS group were provided at 7 days after the cast was removed. The extensor (extensor digitorum longus and tibialis anterior) and flexor (soleus， plantaris， medial gastrocnemius and lateral gastrocnemius) muscles were isolated and weighed. Muscle weight and relative muscle weight were significantly lower in the CAS g roup than in the sedentary control group， whereas these weights were significantly higher in the RCAS group than in the CAS group， except for the soleus muscle. In the CAS group， plantar flexion muscles were more atrophied than dorsal flexion muscles. In the CAS and the RCAS groups， no statistical differences were found between plantar and dorsal flexion muscle weight relativeto muscle weights of the sedentary control group. In particular， the soleus muscle atrophied extensively and did not recover completely. These results indicate that the effects of cast immobilization and cast immobilization off are different between plantar flexion muscles and dorsal flexion muscles.

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