Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia

• 宮崎, 敏樹

• Anan, Shota

• Ishida, Eiichi

• Kawashita, Masakazu

抄録

Recently, organic–inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20–30 μm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol–gel process was also investigated. The obtained hollow microspheres contained particles of size 20–30 μm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.

Journal Article

収録刊行物

• Journal of Materials Science: Materials in Medicine

  Journal of Materials Science: Materials in Medicine 24 (5), 1125-1129, 2013-05-01

  Springer

キーワード

• Carboxymethyldextran
• Magnetite
• Organic–inorganic hybrid
• Microsphere
• Silica coating
• Chemical stability

詳細情報

• CRID: 1050564288864228352
• NII論文ID: 120005646807
• ISSN: 09574530
• ISSN: 15734838
• HANDLE: 10228/5469
• Web Site: https://kyutech.repo.nii.ac.jp/records/4255
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles