Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva
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- Oikawa Junko
- Department of Public Health, Hokkaido University Graduate School of Medicine Department of Public Health, Chiba University Graduate School of Medicine
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- Ukawa Shigekazu
- Department of Public Health, Hokkaido University Graduate School of Medicine
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- Ohira Hideki
- Department of Psychology, Graduate School of Environmental Studies, Nagoya University
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- Kawamura Takashi
- Kyoto University Health Service
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- Wakai Kenji
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Ando Masahiko
- Center for Advanced Medicine and Clinical Research, Hospital, Nagoya University
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- Hata Akira
- Department of Public Health, Chiba University Graduate School of Medicine
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- Tamakoshi Akiko
- Department of Public Health, Hokkaido University Graduate School of Medicine
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Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people.<BR>Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status.<BR>Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 µg/min vs 15.0 µg/min, P = 0.03), even after elimination of the effects of possible confounders.<BR>Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.
収録刊行物
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- Journal of Epidemiology
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Journal of Epidemiology 25 (7), 470-474, 2015
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詳細情報 詳細情報について
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- CRID
- 1390282679451841664
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- NII論文ID
- 120005647270
- 130005086222
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- ISSN
- 13499092
- 09175040
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- HANDLE
- 2115/59746
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- PubMed
- 26094794
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可