Isolation and characterization of a novel alphaherpesvirus in fruit bats.

• Sasaki, Michihito

• Setiyono, Agus

• Handharyani, Ekowati

• Kobayashi, Shintaro

• Rahmadani, Ibenu

• Taha, Siswatiana

• Adiani, Sri

• Subangkit, Mawar

• Nakamura, Ichiro

• Sawa, Hirofumi

• Kimura, Takashi

抄録

Bats are known to harbor emerging RNA viruses. Recent studies have used high-throughput sequencing technology to identify various virus species, including DNA viruses that are harbored by bats; however, little is known about the nature of these potentially novel viruses. Here, we report the characterization of a novel herpesvirus isolated from an Indonesian pteropodid bat. The virus, tentatively named fruit bat alphaherpesvirus 1 (FBAHV1), has a double-stranded DNA genome of 149,459 bp. The phylogenetic analyses suggested that FBAHV1 is phylogenetically grouped with simplexviruses within the subfamily Alphaherpesvirinae. Inoculation of FBAHV1 into laboratory mice caused a lethal infection. Virus infection was observed in lung, liver, and brain tissue. Serological and PCR screening revealed that fruit bats infected with FBAHV1 or its related virus are widely distributed in Indonesia. The identification of FBAHV1 makes a considerable contribution to our understanding of simplexviruses associated with bats.

収録刊行物

• Journal of virology

  Journal of virology 88 (17), 9819-9829, 2014-09

  American Society for Microbiology

詳細情報

• CRID: 1050001339019223296
• NII論文ID: 120005652750
• NII書誌ID: AA12024806
• ISSN: 10985514
• ISSN: 0022538X
• HANDLE: 2115/59849
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles