Safety Evaluation of Wood–Based Activated Carbon Fibers in a 28–day Feeding Study in Sprague–Dawley Rats

DOI HANDLE オープンアクセス
  • Lin Han Chien
    Laboratory of Environment Functional Materials, Department of Wood Based Materials and Design, College of Agriculture, National Chiayi University
  • Hsueh Ji Cheng
    Graduate Institute of Food Science, College of Life Science, National Chiayi University : Master's Program
  • Li Wen-Ru
    Graduate Institute of Wood Based Materials and Design, College of Agriculture, National Chiayi University, Chiayi : Master's Program
  • Lai Ying-Jang
    Department of Food Science, College of Science and Engineering, National Quemoy University
  • Wu She–Ching
    Department of Food Science, College of Life Science, National Chiayi University
  • 藤本 登留
    九州大学大学院農学研究院環境農学部門サスティナブル資源科学講座

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抄録

As a possible food moisture–proof material, wood–based activated carbon fibers (WACFs), prepared from one type of wood pulp: Laubholz Unbleached Kraft Pulp (LUKP) by the physical activation method with steam at an 850°C activation temperature with 60min of activation time (850 LUKP WACFs), were evaluated in a 28–day feeding study of Sprague–Dawley rats (SD rats) after the Ames test had been carried out in a previous paper. SD rats were randomly distributed into five groups, including a blank group (reverse osmosis water), a control group (saline), and groups with low, moderate, and high (1.0, 2.5, and 5.0 g/kg/day, respectively) doses of 850 LUKP WACFs. All SD rats were sacrificed after a 28–day feeding toxicity study. Blood samples were analyzed for hematological and serum biochemical values, and histopathological examinations of the organs were investigated. There were insignificant differences from the clinical pathology; that is, no observable adverse effect levels (NOAEL) of 850 LUKP WACFs greater than 5.0 g/kg/day. It is suggested that WACFs prepared from wood pulp can be a potential type of food moisture–proof material and a potential type of material for water quality improvement due to their biological safety results.

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詳細情報

  • CRID
    1390290699661535360
  • NII論文ID
    120005661378
  • NII書誌ID
    AA00247166
  • DOI
    10.5109/1543405
  • HANDLE
    2324/1543405
  • ISSN
    00236152
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • IRDB
    • Crossref
    • CiNii Articles

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