Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use

• Arsiningtyas, Ines Septi

• Gunawan-Puteri, Maria D. P. T.

• Kato, Eisuke

• Kawabata, Jun

抄録

A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using a-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidated by mass spectrometry and NMR analysis and completed by comparison with reference data. 3,5-Di-O-caffeoylquinic acid (1), 4,5-di-O-caffeoylquinic acid methyl ester (2), 3,4,5-tri-O-caffeoylquinic acid methyl ester (3), 3,4,5-tri-O-caffeoylquinic acid (4) and 1,3,4,5-tetra-O-caffeoylquinic acid (5) were isolated. Comparison of the activities of each isolate suggested that both methyl esterification of quinic acid and the number of caffeate groups in the molecule were important for the inhibitory activity. This study provides basic information for further examination of the suitability of P. indica as a functional food and medicinal supplement for the treatment and prevention of diabetes.

収録刊行物

• Natural Product Research

  Natural Product Research 28 (17), 1350-1353, 2015-10-15

  Taylor & Francis

キーワード

• Indonesian herb
• intestinal maltase inhibitor
• diabetes mellitus
• Pluchea indica
• caffeoylquinic acid derivatives

詳細情報

• CRID: 1050282677651782656
• NII論文ID: 120005661429
• HANDLE: 2115/60048
• ISSN: 14786419
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles