A Novel Mouse Model of Spontaneous Pulmonary Emphysema: Mayumi-Emphysema Mouse

• Shimbori, Chiko

• Takechi, Mayumi

• Shiota, Naotaka

• Nibayashi, Tomomi

• Tanaka, Tetsuya

• Okunishi, Hideki

抄録

Mayumi-Emphysema （ME） mice, which develop spontaneous pulmonary emphysema, were established from wild type C57BL/6J mice. ME mice showed air space enlargement from 2 weeks of age and rapidly developed severe emphysema. The mean linear intercept of the lungs in ME mice was higher than that in control mice at the age of 2 weeks and increased progressively with age in ME mice. However, there was no infiltration of inflammatory cells into the interstitium or alveolar air spaces in the lungs of ME mice. The serum α1-antitrypsin protein level was slightly decreased in ME mice at 4 weeks of age. In ME mice, lung destruction was not associated with an inflammatory reaction, and a slight decrease in serum α1-antitrypsin may be insufficient to induce severe emphysema in ME mice. Hereditary impairment of the normal developmental mechanism for alveoli in the early stage and an abnormal lung structure may induce spontaneous pulmonary emphysema in ME mice.

収録刊行物

• Shimane journal of medical science

  Shimane journal of medical science 32 (1), 19-26, 2015-09-01

  Shimane University Faculty of Medicine

キーワード

• naturally occurring emphysema
• mice model
• C57BL/6 background

詳細情報

• CRID: 1050001339310323456
• NII論文ID: 120005665884
• NII書誌ID: AA00841586
• ISSN: 03865959
• Web Site: http://ir.lib.shimane-u.ac.jp/34461
• Web Site: https://search.jamas.or.jp/link/ui/2017000327
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles