Final‐Stage Site‐Selective Acylation for the Total Syntheses of Multifidosides A–C

• Ueda, Yoshihiro

• Furuta, Takumi

• 川端, 猛夫

書誌事項

タイトル別名

• Final-Stage Site-Selective Acylation for the Total Syntheses of Multifidosides A-C.

抄録

The first total syntheses of multifidosides A-C have been achieved. The synthetic strategy is characterized by catalytic site-selective acylation of unprotected glycoside precursors in the final stage of the synthesis. High functional-group tolerance of the site-selective acylation, promoted by an organocatalyst, enabled the conventionally difficult molecular transformation in a predictable and reliable manner. An advantage of this strategy is to avoid the risks of undesired side reactions during the removal of the protecting groups at the final stage of the total synthesis.

Article first published online: 28 AUG 2015

収録刊行物

• Angewandte Chemie: International Edition

  Angewandte Chemie: International Edition 54 (41), 11966-11970, 2015-10-05

  wiley

キーワード

• acylation
• glycosides
• natural products
• organocatalysis
• synthetic methods

詳細情報

• CRID: 1050845760748957824
• NII論文ID: 120005678203
• NII書誌ID: AA0052535X
• ISSN: 14337851
• ISSN: 15213773
• DOI: 10.1002/anie.201504729
• HANDLE: 2433/202609
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201504729
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201504729
• 本文言語コード: en
• 資料種別: journal article
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