Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway
この論文をさがす
抄録
A histone acetyltransferase Tat-interacting protein 60 kDa (Tip60) regulates the DNA damage response by acetylating histone and remodeling chromatin. In addition to histone acetyltransferase activity, Tip60 is known to regulate a variety of cellular functions, including gene expression, DNA damage response, cell migration and apoptosis. Lower expression of Tip60 is observed in lymphomas, melanomas, breast, colon, and lung cancer. It is widely accepted that Tip60 functions as a tumor suppressor. However, a role of Tip60 in gliomas still remains unclear. In this study, we investigated the role of Tip60 in the malignant behavior of human gliomas. By quantitative RT-PCR analysis using fresh human brain tumor tissues from 55 patients, we found that lower Tip60 expression and higher membrane-type 1 matrix metalloproteinase (MT1-MMP) expression are associated with advanced tumor grade in glioma tissues. Knockdown of Tip60 in glioblastoma cells promoted cell adhesion, spreading and MT1-MMP transcription and thereby invasion, which was suppressed by inhibition of MT1-MMP and nuclear factor-kappa B (NF-κB) activity. We demonstrate for the first time that tumor suppressor Tip60 down-regulates cell adhesion and MT1-MMP expression and thereby invasion of glioblastoma cells by suppressing NF-κB pathway. © 2015 Springer Science+Business Media Dordrecht
Embargo Period 12 months
収録刊行物
-
- Clinical and Experimental Metastasis
-
Clinical and Experimental Metastasis 33 (1), 45-52, 2016-01-01
Springer Verlag
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390857445997554176
-
- NII論文ID
- 120005680038
-
- NII書誌ID
- AA1064065X
-
- ISSN
- 02620898
-
- Web Site
- http://hdl.handle.net/2297/43905
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- CiNii Articles