NON-INVASIVE METHOD FOR PREDICTING HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATIC DISEASE BY MEASURING THE SHEAR WAVE VELOCITY

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Aim : To evaluate the usefulness of acoustic radiation force impulse (ARFI) in predicting hepatocellular carcinoma (HCC) in patients with chronic hepatic disease (CHD). Methods : A total of 230 patients participated in this study. They were subsequently classified into the “HCC group” and the “non-HCC group”. We measured their liver stiffness and calculated the mean shear wave velocity (SWV) using ARFI. Results : The mean SWV was significantly higher in the HCC group than in the non-HCC group. The cut-off value for the mean SWV with the best discrimination between the two groups was 1.36 (m/s). The area under the receiver operating characteristic curve (AUROC) was 0.807. The AUROCs of the aspartate-aminotransferase-to-platelet ratio and Fibrosis 4 score were 0.780, 0.728, respectively. The independent risk factors of HCC included the mean SWV and age. A further analysis, based on the individual causes of CHD, found that among the HCV and non-HBV and non-HCV (nBnC) cases, the mean SWV was significantly higher in the HCC group than in the non-HCC group. Conclusion : Measuring the SWV using ARFI was a reliable method for predicting HCC in CHD patients, especially in HCV and nBnC patients.

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  • 秋田医学

    秋田医学 43 (1), 39-49, 2016-06-30

    秋田医学会

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