新規強心薬SCH00013のモルモット心臓に対する作用

書誌事項

タイトル別名
  • Actions of a New Cardiotonic Agent, SCH00013, on Guinea-pig Heart
  • シンキキョウシンヤクSCH00013ノモルモットシンゾウニタイスルサヨウ

この論文をさがす

抄録

A new cardiotonic agent, SCH00013 (SCH), which was synthesized by Zenyaku Kogyo Company, Limited, exhibits cardiotonic effects by enhancing calcium sensitivity [1]. In this study, we examined the inotropic and chronotropic effects of SCH usin right atrial muscles extirpated from guinea pigs. Although 10 - 4 M SCH showed positive inotropic effects (50% of those of noradrenaline (NAd)), there was no increase in the heart rate. In addition, we measured changes in the left ventricular diastolic pressure (LVDP) and transient Ca 2 + (TCa) signals in Fura-2-loaded Langendorff hearts. The administration of 10 -5 M SCH decreased the level of TCa, whereas 10 - 4 M SCH administration increased it. On the other hand, pimobendan (PIM), which is used as a drug for heart failure due to its calcium sensitivity-enhancing actions, decreased the level of TCa at 10 - 4 M despite an increase in contractility. This suggests that the mechanism of Ca 2+ contractile protein system sensitivity differs between SCH and PIM. As SCH does not increase the heart rate in the presence of heart failure, it may protect the cardiac muscle.

収録刊行物

詳細情報

問題の指摘

ページトップへ