Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome

• Wada, Taizo

• Matsuda, Yusuke

• Toma, Tomoko

• Koizumi, Eiko

• Okamoto, Hiroyuki

• Yachie, Akihiro

抄録

Background: Food protein-induced enterocolitis syndrome (FPIES) is an uncommon, non-IgE-mediated food allergy. We recently described a significant increase in fecal eosinophil-derived neurotoxin (EDN) after ingestion of the causative food. However, little is known about the activation status of circulating eosinophils in patients with an acute FPIES reaction. Methods: Surface CD69 expression was assessed by flow cytometry on peripheral eosinophils from 5 patients with FPIES before and after ingestion of the causative food. Fecal EDN was measured by enzyme-linked immunosorbent assay. Results: No eosinophil activation was observed before ingestion; however, a significant increase in CD69 expression on eosinophils after an acute FIPES reaction was demonstrated in all of the patients. There was no significant change in absolute eosinophil counts in the peripheral blood. The levels of fecal EDN increased on the day after ingestion of the causative food in all patients. Conclusion: These results suggest that circulating eosinophils as well as eosinophils in the intestinal mucosal tissue are activated in acute FPIES reactions and might be associated with systemic immune events in FPIES. © 2016 S. Karger AG, Basel.

Embargo Period 12 months

収録刊行物

• International Archives of Allergy and Immunology

  International Archives of Allergy and Immunology 170 (3), 201-205, 2016-09-01

  S. Karger AG

キーワード

• CD69
• Eosinophil-derived neurotoxin
• Eosinophils
• Food protein-induced enterocolitis syndrome

詳細情報

• CRID: 1050001335983947648
• NII論文ID: 120005851365
• NII書誌ID: AA10838704
• ISSN: 10182438
• Web Site: http://hdl.handle.net/2297/46165
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles