Expression of Tim-1 in primary CNS lymphoma

• 錦織, 桃子

• 北脇, 年雄

• 羽賀, 博典

• Miyoshi, Hiroaki

• Sasaki, Yuya

• Kitawaki, Toshio

• Shirakawa, Kotaro

• Kato, Takeharu

• Imaizumi, Yoshitaka

• Ishikawa, Takayuki

• Ohno, Hitoshi

• Haga, Hironori

• Ohshima, Koichi

• Takaori-Kondo, Akifumi

抄録

Primary central nervous system lymphoma (PCNSL) is a distinct subtype of extranodal lymphoma with aggressive clinical course and poor outcome. As increased IL-10/IL-6 ratio is recognized in the cerebrospinal fluid (CSF) of PCNSL patients, we hypothesized that PCNSL might originate from a population of B cells with high IL-10-producing capacity, an equivalent of "regulatory B cells" in mice. We intended in this study to clarify whether Tim-1, a molecule known as a marker for regulatory B cells in mice, is expressed in PCNSL. By immunohistochemical analysis, Tim-1 was shown to be positive in as high as 54.2% of PCNSL (26 of 58 samples), while it was positive in 19.1% of systemic diffuse large B-cell lymphoma (DLBCL) samples (17 of 89 samples; P < 0.001). Tim-1 expression positively correlated with IL-10 expression in PCNSL (Cramer's V = 0.55, P < 0.001), and forced expression of Tim-1 in a PCNSL cell line resulted in increased IL-10 secretion, suggesting that Tim-1 is functionally linked with IL-10 production in PCNSL. Moreover, soluble Tim-1 was detectable in the CSF of PCNSL patients, and was suggested to parallel disease activity. In summary, PCNSL is characterized by frequent Tim-1 expression, and its soluble form in CSF may become a useful biomarker for PCNSL.

収録刊行物

• Cancer Medicine

  Cancer Medicine 5 (11), 3235-3245, 2016-10-05

  Wiley-Blackwell

キーワード

• Biomarker
• Central nervous system
• Diffuse large B-cell lymphoma
• Immunohistochemistry
• Tim-1

詳細情報

• CRID: 1050564285791824000
• NII論文ID: 120005867107
• ISSN: 20457634
• HANDLE: 2433/217325
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles