書誌事項
- タイトル別名
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- Interaction between Viral Proteins and Mitochondria
- ウイルスタンパクシツ ト ミトコンドリア ト ノ ソウゴ サヨウ
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抄録
Recent advances reveal that mitochondria are not limited to functioning only as the cellular powerhouse and in apoptosis, but that they act as central hubs for multiple signal transductions. Studies over the last decade indicate that mitochondria in vertebrates are involved in the front line of host defense, especially against RNA viruses. Mitochondrial-mediated antiviral innate immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway, and the mitochondrial surface acts as a platform for the assembly of signaling molecules, including mitochondrial antiviral signaling (MAVS) during the process. Some viral encoded proteins target to the mitochondria post-infection, however, thereby evading the cellular immune response. Here we review specific interactions between mitochondria and viral proteins and discuss their physiologic effects on the host cells.
収録刊行物
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- 福岡醫學雜誌
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福岡醫學雜誌 107 (8), 148-154, 2016-08-25
福岡医学会
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詳細情報 詳細情報について
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- CRID
- 1390290699741429248
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- NII論文ID
- 120005893255
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- NII書誌ID
- AN00215478
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- DOI
- 10.15017/1785664
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- HANDLE
- 2324/1785664
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- NDL書誌ID
- 027840204
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- ISSN
- 0016254X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用可