A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men
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抄録
In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 SNP is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this single nucleotide polymorphism (SNP) is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (βSTD = 0.15, P = 9.7 × 10-5), sperm concentration (βSTD = 0.073, P = 0.032), and total sperm number (TSN) (βSTD = 0.074, P = 0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production.
収録刊行物
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- Journal of Human Genetics
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Journal of Human Genetics 61 (11), 911-915, 2016-11
Tokyo : Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050845762395171840
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- NII論文ID
- 120005951705
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- NII書誌ID
- AA11206160
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- ISSN
- 14345161
- 1435232X
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- NDL書誌ID
- 027735885
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
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- CiNii Articles
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