Concomitant T790M mutation and small-cell lung cancer transformation after acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor

• 金, 永学

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• 吉澤, 明彦

  Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University

• 三嶋, 理晃

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Mio, Tadashi

• Mishima, Michiaki

抄録

A 70-year-old man was admitted to our hospital with an abnormal chest X-ray shadow. Bronchoscopy revealed an adenocarcinoma tumour with an epidermal growth factor receptor (EGFR) exon 19 deletion. Positron emission tomography-computed tomography scanning and magnetic resonance imaging showed advanced stage IV lung cancer. He was treated with erlotinib as a first-line drug, which maintained a clinical response for 16 months. After disease progression, a re-biopsy was done from the tumour in the right lower lobe. The obtained specimen harboured both small-cell lung cancer (SCLC) transformation with retention of the EGFR 19 deletion and the development of an EGFR T790M mutation. We came across a very rare condition of concomitant T790M mutation and SCLC transformation after acquired resistance to EGFR-tyrosine kinase inhibitor.

収録刊行物

• Respirology Case Reports

  Respirology Case Reports 5 (1), 2017-01-01

  Wiley-Blackwell Publishing Ltd

キーワード

• Adenocarcinoma
• Epidermal growth factor receptor-tyrosine kinase inhibitor
• Small-cell lung cancer transformation
• T790M mutation

詳細情報

• CRID: 1050282810817763072
• NII論文ID: 120005973346
• ISSN: 20513380
• HANDLE: 2433/218320
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles