Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

• Adachi, Yasushi

• Nojima, Masanori

• Mori, Mitsuru

• Yamashita, Kentaro

• Yamano, Hiro-o

• Nakase, Hiroshi

• Endo, Takao

• Wakai, Kenji

• Sakata, Kiyomi

• Tamakoshi, Akiko

抄録

AIM: To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma. METHODS: We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels. RESULTS: Thirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95% CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150). CONCLUSION: The free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.

収録刊行物

• World Journal of Gastroenterology

  World Journal of Gastroenterology 23 (19), 3488-3495, 2017-05-21

  Baishideng Publishing Group

キーワード

• Esophageal cancer
• Insulin-like growth factor
• Insulin-like growth factor binding protein
• Nested case-control study
• Odds ratio

詳細情報

• CRID: 1050282813999762944
• NII論文ID: 120006329016
• HANDLE: 2115/66888
• ISSN: 10079327
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles