A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody

• Yamazaki Kenji

• Wakabayashi Hiroshi

• Suganami Yu

• Sano Shinichi

• Wakunami Yu

• Katayama Takashi

• Deguchi Kentaro

• Nagotani Shoko

• Kishida Masayuki

抄録

We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 71 (4), 341-344, 2017-08

  Okayama University Medical School

キーワード

• dermatomyositis
• anti-melanoma differentiation-associated gene 5 antibody
• interstitial lung disease
• pneumomediastinum

詳細情報

• CRID: 1390853649749816960
• NII論文ID: 120006333882
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/55311
• PubMed: 28824190
• Web Site: https://ousar.lib.okayama-u.ac.jp/55311
• Web Site: https://search.jamas.or.jp/link/ui/2018212382
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles