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Abstract
金沢大学医薬保健研究域薬学系
In this study, fruit fly of the genus Drosophila is utilized as a suitable model animal to investigate the molecular mechanisms of innate immunity. To combat orally transmitted pathogenic Gram-negative bacteria, the Drosophila gut is armed with the peritrophic matrix, which is a physical barrier composed of chitin and glycoproteins: the Duox system that produces reactive oxygen species (ROS), which in turn sterilize infected microbes, and the IMD pathway that regulates the expression of antimicrobial peptides (AMPs), which in turn control ROS-resistant pathogens. However, little is known about the defense mechanisms against Gram-positive bacteria in the fly gut. Here, we show that the peritrophic matrix protects Drosophila against Gram-positive bacteria S. aureus. We also define the few roles of ROS in response to the infection and show that the IMD pathway is required for the clearance of ingested microbes, possibly independently from AMP expression. These findings provide a new aspect of the gut defense system of Drosophila, and helps to elucidate the processes of gut-microbe symbiosis and pathogenesis. © 2017 The Authors.
Embargo Period 12 months
Journal
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- Biochemical and Biophysical Research Communications
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Biochemical and Biophysical Research Communications 495 (1), 395-400, 2018-01-01
Elsevier B.V.
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Details 詳細情報について
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- CRID
- 1390009224960262528
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- NII Article ID
- 120006375092
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- NII Book ID
- AA00564395
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- ISSN
- 0006291X
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- Web Site
- http://hdl.handle.net/2297/00049486
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- CiNii Articles