Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma
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- Aoyama Yumi
- Departments of Hematology and
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- Kodaka Taiichi
- Departments of Hematology and
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- Zushi Yuriko
- Cell Therapy, Shinko Hospital, and
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- Goto Yuta
- Departments of Hematology and
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- Tsunemine Hiroko
- Departments of Hematology and
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- Itoh Tomoo
- Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
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- Takahashi Takayuki
- Departments of Hematology and
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抄録
<p>Composite lymphoma is defined as the co-occurrence of two types of lymphoma, comprising 1-4% of lymphomas, and the association of B-cell-type chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma and peripheral T-cell lymphoma (PTCL) is rare. Here, we report a case (77-year-old woman) of advanced B-CLL complicated by newly appearing PTCL. Two years after the onset of B-CLL, CLL cells acquired CD38 antigen expression and the disease entity became CLL/prolymphocytic leukemia. Trisomy 12 and t(14;18) karyotypes were observed. Five years after the onset of B-CLL, large abnormal cells with convoluted nuclei appeared in the peripheral blood and rapidly increased in number. These cells were positive for CD3, CD4, CD5, CD30 (partially), CD56, and αβ-type T-cell receptor (TCR), in which PCR demonstrated monoclonal TCR-γ gene rearrangement. An additional diagnosis of PTCL, not otherwise specified was made. We treated her with an R-CHOP regimen, resulting in the marked reduction of B-CLL cells but progressive PTCL. Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia. This case is highly informative for tumor biology of B-CLL in terms of emergence of both chromosomal abnormalities and PTCL with progression of this leukemia.</p>
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 58 (1), 27-31, 2018
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詳細情報 詳細情報について
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- CRID
- 1390001204703412480
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- NII論文ID
- 130006512994
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- ISSN
- 18809952
- 13464280
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- HANDLE
- 20.500.14094/90004838
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- PubMed
- 29415977
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可