Factors Associated with Increased Levels of Brain Natriuretic Peptide and Cardiac Troponin I during the Peripartum Period

• 加藤, 貴雄

  Cardiovascular Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital

• Kato, Takao

  Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

• Miyata, Hiromi

  Department of Obstetrics and Gynecology, Tazuke Kofukai Medical Research Institute, Kitano Hospital

• Sasaki, Issei

  Department of Health and Sports Sciences, Kyoto Pharmaceutical University

• Minamino-Muta, Eri

  Cardiovascular Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital

• Nagasawa, Yoshinori

  Department of Health and Sports Sciences, Kyoto Pharmaceutical University

• Numao, Shigeharu

  Department of Health and Sports Sciences, Kyoto Pharmaceutical University

• Nagano, Tadayoshi

  Department of Obstetrics and Gynecology, Tazuke Kofukai Medical Research Institute, Kitano Hospital

• Higuchi, Toshihiro

  Department of Obstetrics and Gynecology, Tazuke Kofukai Medical Research Institute, Kitano Hospital

• Inoko, Moriaki

  Cardiovascular Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital

抄録

Background: We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. Methods and results: We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed their laboratory data and echocardiographic findings during the third trimester (28–30 weeks’ gestation) and within 4 days of delivery. In addition, we evaluated the factors associated with elevation of BNP and cardiac troponin I (cTnI) levels. The pregnant women were 33.8 ± 5.0 years old and the prevalence of pregnancy induced hypertension (PIH) and placental abnormality was 4.2% and 2.5%, respectively. BNP levels increased after delivery (13.2 pg/mL vs. 23.5 pg/mL; P <0.001), correlated with increased left ventricular diastolic dimension (P = 0.035), left atrial dimension (P <0.001), and decreased hemoglobin (P <0.001). Moreover, cTnI levels increased to over 0.015 ng/mL after delivery in 4.0% of pregnant women. In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. Conclusions: BNP levels increased in association with cardiac chamber enlargement and decreased hemoglobin after delivery. Additionally, the factors affecting elevated cTnI levels were related to labor and delivery.

収録刊行物

• PLOS ONE

  PLOS ONE 14 (2), 2019-02-07

  Public Library of Science (PLoS)

詳細情報

• CRID: 1050564288162678528
• NII論文ID: 120006554786
• ISSN: 19326203
• HANDLE: 2433/236374
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles