Importance of finding the bona fide target of the Fanconi anemia pathway

• 酒井, 恒

• 菅澤, 薫

抄録

Fanconi anemia (FA) is a rare genetic disease characterized by the deficiency of the cellular response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent studies have revealed the detailed molecular functions of FA proteins encoded by 22 genes, the mechanism of occurrence of endogenous ICLs in the human body remains poorly understood. In this short review, we summarize the potential endogenous sources of ICLs counteracted by FA proteins, and provide perspectives on the unanswered questions regarding FA.

収録刊行物

• Genes and Environment

  Genes and Environment 41 6-6, 2019-03-06

  BMC

キーワード

• Fanconi anemia
• Aldehyde
• DNA damage
• DNA repair

詳細情報

• CRID: 1050012570392898560
• NII論文ID: 120006619818
• DOI: 10.1186/s41021-019-0122-y
• ISSN: 18807062
• HANDLE: 20.500.14094/90005873
• Web Site: http://link.springer.com/content/pdf/10.1186/s41021-019-0122-y.pdf
• Web Site: http://link.springer.com/article/10.1186/s41021-019-0122-y/fulltext.html
• Web Site: https://search.jamas.or.jp/link/ui/2020221382
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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