Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C

• Chuma Masayuki

• Kondo Masateru

• Zamami Yoshito

• Takechi Kenshi

• Goda Mitsuhiro

• Okada Naoto

• Shibata Akitomo

• Asada Mizuho

• Oto Jun

• Yanagawa Hiroaki

• Ishizawa Keisuke

抄録

Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 74 (4), 365-370, 2020-08

  Okayama University Medical School

キーワード

• vancomycin,
• therapeutic drug monitoring
• cystatin C
• bacterial meningitis
• sepsis

詳細情報

• CRID: 1390290699799674880
• NII論文ID: 120006880215
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/60376
• Web Site: https://ousar.lib.okayama-u.ac.jp/60376
• Web Site: https://search.jamas.or.jp/link/ui/2021209288
• 本文言語コード: en
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