Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants

• Otani, Sayo

• 伏見, 育崇

• Iwanaga, Kogoro

• 友滝, 清一

• Yokota, Yusuke

• Oshima, Sonoko

• Sakurama, Azusa

• Wicaksono, Krishna Pandu

• Hinoda, Takuya

• 坂田, 昭彦

• 中島, 諭

• 岡田, 知久

• 滝田, 順子

• 河井, 昌彦

• Togashi, Kaori

抄録

[Background]: Hypothalamic–pituitary–thyroid (HPT) maturation has not been extensively evaluated using neonatal MRI, even though both structures are visualized on MRI. [Hypothesis]: That signal intensity and volume of pituitary and thyroid (T) glands on MRI in neonates may be interrelated. [Study Type]: Retrospective. [Subjects]: In all, 102 participants. [Field Strength/Sequence]: 3.0T, T₁‐weighted pointwise encoding time reduction with radial acquisition (PETRA).[ Assessment]: The volume of interest of the anterior pituitary (AP), posterior pituitary (PP), and T on MRI were defined on T₁‐PETRA by two radiologists, and volumes of AP (AP_vol) and thyroid (T_vol) were calculated. Gestational age (GA), chronological age (CA), GA+CA, birth weight (BW), and thyroid function were recorded. Mean and maximum signal intensities of AP, PP, and T were normalized using signals from the pons and spinal cord as follows: signal ratio of anterior pituitary/pons (AP/pons), signal ratio of posterior pituitary/pons (PP/pons), and signal ratio of thyroid/cord (T/cord) T/cord, respectively. [Statistical Tests]: Correlations between signal intensity and volume measures and GA, CA, GA+CA, and BW were assessed using Pearson's correlation coefficient or Spearman's rank correlation coefficient. Thyroid function analysis and Tmean/cord, Tmax/cord, and T_vol were evaluated using the Steel–Dwass test. Results: APmean/pons correlated positively with GA (ρ = 0.62, P < 0.001) and BW (ρ = 0.74, P < 0.001), and negatively with CA (ρ = −0.86, P < 0.001) and GA+CA (ρ = −0.46, P < 0.001). PPmean/pons correlated positively with GA (ρ = 0.49, P < 0.001) and BW (ρ = 0.63, P < 0.001), and negatively with CA (ρ = −0.70, P < 0.001) and GA+CA (r = −0.38, P < 0.001). Tmean/cord correlated positively with GA (ρ = 0.48, P < 0.001) and BW (ρ = 0.55, P < 0.001), and negatively with CA (ρ = −0.59, P < 0.001) and GA+CA (ρ = −0.22, P = 0.03). AP_vol correlated positively with GA (ρ = 0.68, P < 0.001) and BW (ρ = 0.73, P < 0.001), and negatively with CA (ρ = −0.72, P < 0.001). T_vol correlated positively with GA (ρ = 0.50, P < 0.001) and BW (ρ = 0.61, P < 0.001), and negatively with CA (ρ = −0.54, P < 0.001). APmean/pons correlated positively with Tmean/cord (ρ = 0.61, P < 0.001). [Data Conclusion]: Signal and volume of pituitary and thyroid glands correlated positively with GA and BW, and negatively with CA in neonates. [Level of Evidence]: 4 [Technical Efficacy Stage]: 5

収録刊行物

• Journal of Magnetic Resonance Imaging

  Journal of Magnetic Resonance Imaging 53 (4), 1151-1161, 2021-04

  Wiley

キーワード

• pituitary gland
• thyroid gland
• hypothalamic–pituitary‐thyroid axis
• preterm infant
• PETRA

詳細情報

• CRID: 1050569302453353344
• NII論文ID: 120007026445
• ISSN: 15222586
• ISSN: 10531807
• HANDLE: 2433/262574
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles