Growth and solvent-mediated phase transition of cimetidine polymorphic forms A and B.

• Sudo Shogo

  Department of Applied Chemistry, Faculty of Engineering, Osaka City University

• Sato Katsutoshi

  Department of Applied Chemistry, Faculty of Engineering, Osaka City University

• Harano Yoshio

  Department of Applied Chemistry, Faculty of Engineering, Osaka City University

抄録

For the organic compound cimetidine, which has seven polymorphic forms, the growth rates of form A (metastable) and B (stable) and the solvent-mediated phase transition rates from A to B were measured in 2-propanol solvent. At high supersaturation ratio (S_C,A = 3.6), with form-A seed, agglomerated crystals of form A were obtained without an induction period. With form-B seed, by contrast, form A nucleated heterogeneously on B seed’s surface and then grew to single-like crystals after the induction period. At low supersaturation ratio (S_A ≤ 1.3, S_B ≤ 1.7), the growth rate of form A was higher than that of form B at the same supersaturation ratio, S_i, based on their respective solubilities, but at the same solute concentration this tendency was reversed. At S_A = 1.0, a solvent-mediated phase transition took place, being controlled by the growth rate of form B. The growth rates of both forms at low supersaturation were proportional to the surface area of crystal and (S_i – 1)².

収録刊行物

• JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

  JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 24 (5), 628-632, 1991

  公益社団法人 化学工学会

キーワード

• Crystallization
• Polymorphism
• Growth Rate
• Phase Transition
• Seed Effect

詳細情報

• CRID: 1390282679541991168
• NII論文ID: 130000021720
• DOI: 10.1252/jcej.24.628
• COI: 1:CAS:528:DyaK38XlvVKnuw%3D%3D
• ISSN: 18811299
• ISSN: 00219592
• ISSN: http://id.crossref.org/issn/00219592
• Web Site: http://www.jstage.jst.go.jp/article/jcej/24/5/24_5_628/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可