A Method to Support Cell Physiological Modelling Using Description Language and Ontology
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- Shimayoshi Takao
- ASTEM Research Institute of Kyoto
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- Komurasaki Kazuhiro
- Graduate School of Informatics, Kyoto University
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- Amano Akira
- Graduate School of Informatics, Kyoto University
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- Iwashita Takeshi
- Academic Center for Computing and Media Studies, Kyoto University
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- Matsuda Tetsuya
- Graduate School of Informatics, Kyoto University
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- Kanazawa Masanori
- Academic Center for Computing and Media Studies, Kyoto University
抄録
The development of physiological cell models to support the understanding of biological mechanisms gains increasingly importance. Due to the complexity of biological systems, whole cell models, which are composed of many imported component models of functional elements, get quite complex, making modifications difficult. Here, we propose a method to enhance structural changes of cell models, employing the markup languages of CellML and our original PMSML (Physiological Model Structure Markup Language), in addition to a new ontology for cell physiological modelling, the Cell Model Ontology. In particular, a method to make references from CellML files to the ontology and a method to assist with manipulation of model structures using PMSML together with the Cell Model Ontology are reported. Using these methods two software utilities, an interactive ontology ID assigner, the CellML Ontologizer, and a graphical cell model editor, the Cell Structure Editor, are implemented. Experimental results proved that the proposed method and the implemented software are useful for the modification of physiological models.
収録刊行物
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- IPSJ Digital Courier
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IPSJ Digital Courier 2 726-735, 2006
一般社団法人 情報処理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680200404992
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- NII論文ID
- 130000022295
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- ISSN
- 13497456
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可